Thorne Methyl-Guard Plus® - Advanced Methylation Support with Active B Vitamins

Cardiovascular & Homocysteine Support: Methyl-Guard Plus® provides methylated B vitamins that serve as essential cofactors in homocysteine metabolism, helping convert this amino acid into methionine and cysteine through the methylation and transsulfuration pathways. Elevated homocysteine levels are associated with cardiovascular concerns, and this formula's combination of 5-MTHF (400 mcg), methylcobalamin (400 mcg), vitamin B6 as P5P (10 mg), and riboflavin (7.5 mg) works synergistically to support healthy homocysteine levels already within normal range, promoting optimal cardiovascular function and vascular integrity.

Neurological Function & Cognitive Health: The neurologically active forms of B vitamins in this formula cross the blood-brain barrier efficiently to support neurotransmitter synthesis, including serotonin, dopamine, and norepinephrine production. Methylcobalamin supports myelin sheath formation and nerve cell communication, while 5-MTHF provides methyl groups essential for DNA methylation patterns that regulate gene expression in neural tissue. This comprehensive support promotes healthy mood balance, cognitive clarity, and optimal nervous system function throughout life.

Methylation Pathway Optimization: This advanced formula delivers nutrients in their metabolically active, coenzyme forms that bypass common genetic variations (such as MTHFR C677T and A1298C polymorphisms) that can impair the body's ability to convert synthetic folic acid and cyanocobalamin into usable forms. By providing tissue-ready 5-MTHF, methylcobalamin, and P5P, Methyl-Guard Plus® ensures individuals with reduced enzyme activity can still maintain optimal methylation capacity for DNA synthesis, cellular repair, detoxification processes, and epigenetic regulation regardless of genetic predisposition.

Enhanced Bioavailability & Purity: Thorne's commitment to quality means Methyl-Guard Plus® contains only the most bioavailable forms of nutrients without unnecessary additives, fillers, or common allergens. The inclusion of trimethylglycine (betaine) at 400 mg provides an alternative methyl donor that works independently of folate-dependent pathways, offering additional methylation support. This comprehensive formula also includes riboflavin-5'-phosphate, the active form of vitamin B2 that serves as a cofactor for MTHFR enzyme function, creating a complete methylation support system in a single, convenient daily capsule.