Thorne 5-MTHF 1mg Capsules - Active Methylfolate for Optimal Health

Cardiovascular & Homocysteine Support: 5-MTHF plays a critical role in methylation pathways that convert homocysteine to methionine, helping maintain healthy homocysteine levels already within normal range. Elevated homocysteine is associated with cardiovascular stress, and active folate ensures efficient metabolism of this amino acid, supporting arterial health, endothelial function, and overall cardiovascular wellness through optimal methylation capacity.

Neurological Function & Mood Balance: Methylfolate is essential for neurotransmitter synthesis, particularly serotonin, dopamine, and norepinephrine, which regulate mood, cognition, and emotional wellbeing. By providing folate in its active 5-MTHF form, this supplement ensures the nervous system receives the cofactors needed for healthy brain chemistry, supporting mental clarity, emotional resilience, and cognitive performance without relying on the body's ability to convert synthetic folic acid.

Prenatal & Reproductive Health: Active folate is crucial during preconception and pregnancy for proper neural tube development and fetal growth. Unlike synthetic folic acid, 5-MTHF is immediately bioavailable and doesn't mask vitamin B12 deficiency, making it the superior choice for women planning pregnancy or currently pregnant who need optimal folate status to support healthy fetal development, cellular division, and DNA synthesis throughout all stages of pregnancy.

Superior Bioavailability for MTHFR Variations: Approximately 60% of the population has genetic variations in the MTHFR enzyme that impair the conversion of synthetic folic acid to active folate. Thorne's 5-MTHF bypasses this metabolic bottleneck entirely by providing folate in its metabolically active form, ensuring individuals with MTHFR polymorphisms receive full folate benefits without the accumulation of unmetabolized folic acid that can occur with conventional supplements.